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5-MeO-DMT hydrochloride

5-MeO-DMT hydrochloride properties

Synonym: 5-methoxy-N,N-dimethyltryptamine hydrochloride
CAS Number: n/a
Formula: 3-[2-(dimethylamino)ethyl]-5-methoxyindole hydrochloride
Molar mass: 254.8 g/mol
Purity: >97%

Price range: €25.00 through €360.00

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* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgment of your healthcare professional.

5-MeO-DMT Hydrochloride – Scientific Product Documentation

General Description

5-MeO-DMT hydrochloride (5-Methoxy-N,N-dimethyltryptamine HCl) is a water-soluble salt of the classical tryptamine, particularly suitable for pharmacological research due to its increased stability and bioavailability compared to the freebase form.

Technical Specifications

ParameterSpecification
Chemical FormulaC₁₃H₁₈N₂O · HCl
Molecular Weight254.75 g/mol
Purity≥98% (analyzed by HPLC-UV)
AppearanceWhite to light yellow crystalline powder
SolubilityHigh in water (>50 mg/ml), methanol, PBS
Melting point243-247°C (decomposes)
StabilityHygroscopic; store in dry conditions

Scientific Applications

1. Neuropharmacology & Behavioral Research

  • Serotonin receptor studies: Potent 5-HT₁ₐ/₂ₐ agonist with rapid cerebral penetration.

  • Animal testing (in vivo): Behavioral paradigms (e.g. head-twitch response in rodents).

  • Electrophysiology: Effects on neuronal oscillations (e.g. gamma-band activity).

2. Biochemical & Molecular Studies

  • Intracellular signaling: cAMP accumulation and β-arrestin recruitment assays.

  • Enzyme kinetics: MAO-A metabolism (IC₅₀ ~2-5 μM).

3. Clinically Relevant Research

  • Dose-response relationships: Preclinical safety profiling.

  • Comparative pharmacology: Compared to psilocybin, DMT and other tryptamines.

Experimental Guidelines

Recommended Concentrations

ApplicationConcentration rangeSolvent
Cell cultures (in vitro)1 nM – 10 μMPBS/DMEM (≤0.1% DMSO)
Receptor assays0.1 – 100 μMTris-HCl buffer (pH 7.4)
Animal studies (ip/iv)0.1 – 5 mg/kgSterile saline solution

Safety measures

  • Personal protection: Lab coat, gloves (nitrile), safety glasses.

  • Handling: Hygroscopic – close quickly after use.

  • Storage: Hermetically sealed, under argon, at -20°C (prevent hydrolysis).

Stability & Storage

  • Shelf life:

    • -20°C: >2 years (unchanged purity).

    • 4°C: 6 months (in dry environment).

  • Degradation:

    • Hydrolysis on prolonged exposure to moisture (monitor by HPLC).

Analytical Validation

Each batch comes with:

  1. HPLC-UV chromatogram (C18 column, retention time ~6.2 min).

  2. MS/MS fragmentation (characteristic ions: m/z 219 → 174, 160).

  3. Residual solvents (meet ICH Q3C guidelines).

Legal Status (Netherlands/EU)

  • Narcotics legislation: Not explicitly mentioned in the Opium Act, but possibly under analogous legislation (Appendix II).

  • Scientific use: Permit required for institutions (CCMO approval for animal testing).

  • Export control: Subject to EU Regulation 2019/1998 (psychotropic substances).

Frequently Asked Questions (FAQ)

Q1: What are the advantages of HCl over freebase?
A:

  • Better solubility (ideal for injection studies).

  • Longer shelf stability at room temperature.

Q2: Is 5-MeO-DMT-HCl detectable in drug tests?
A: Yes, via:

  • LC-MS/MS (recognized as 5-MeO-DMT + HCl adduct).

  • Immunoassays: Cross-reactivity with DMT (~15-20%).

Q3: Are there any risks when combined with MAO inhibitors?
A: Absolute:

  • Increased risk of serotonin syndrome (avoid combination!).

  • Use only in MAO-free models.

Q4: How to handle waste?
A:

  1. Neutralize with sodium bicarbonate (pH 7-8).

  2. Adsorb with activated carbon.

  3. Dispose of as hazardous chemical waste (UN 3249, class 6.1).

References & Contact

Core literature:

  1. Shen et al. (2010). “Pharmacology of 5-MeO-DMT derivatives”. J Psychopharmacol.

  2. Kaasik et al. (2021). “Metabolic pathways of 5-MeO-DMT”. Xenobiotics.

This product is intended for authorized scientific research only. Not for human consumption or diagnostic use. Observe local laws.