{"id":340,"date":"2026-02-09T11:52:35","date_gmt":"2026-02-09T11:52:35","guid":{"rendered":"https:\/\/chemicalshoppers.com\/?post_type=product&p=340"},"modified":"2026-02-13T16:12:18","modified_gmt":"2026-02-13T16:12:18","slug":"proscaline-fumarate","status":"publish","type":"product","link":"https:\/\/chemicalshoppers.com\/es\/producto\/proscaline-fumarate\/","title":{"rendered":"Proscaline fumarate"},"content":{"rendered":"

Proscaline Fumaraat \u2013 Wetenschappelijke Productdocumentatie<\/strong><\/h3>\n

\ud83d\udd2c Chemische Specificaties<\/strong><\/h4>\n

Proscaline (4-propoxy-3,5-dimethoxyfenethylamine) fumaraat is een semi-synthetisch phenethylaminederivaat met structurele gelijkenis aan mescaline. Deze onderzoeksverbinding wordt bestudeerd vanwege zijn unieke receptorinteractieprofiel.<\/p>\n

Kernparameters:<\/em><\/p>\n

    \n
  • \n

    IUPAC-naam<\/strong>: 2-(4-propoxy-3,5-dimethoxyphenyl)ethan-1-amine fumaraat<\/p>\n<\/li>\n

  • \n

    Molecuulformule<\/strong>: C\u2081\u2083H\u2082\u2081NO\u2083 \u00b7 C\u2084H\u2084O\u2084<\/p>\n<\/li>\n

  • \n

    Molecuulgewicht<\/strong>: 339,36 g\/mol<\/p>\n<\/li>\n

  • \n

    Zuiverheid<\/strong>: \u226598% (HPLC-UV bij 254 nm)<\/p>\n<\/li>\n

  • \n

    Vorm<\/strong>: Wit kristallijn poeder<\/p>\n<\/li>\n

  • \n

    Smeltpunt<\/strong>: 172-174\u00b0C (ontleedt)<\/p>\n<\/li>\n

  • \n

    Oplosbaarheid<\/strong>: 15 mg\/ml in water, 30 mg\/ml in warm ethanol<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddeb Onderzoeksapplicaties<\/strong><\/h4>\n
      \n
    1. \n

      Receptorbindingsstudies<\/strong>:<\/p>\n

        \n
      • \n

        5-HT\u2082A agonisme (EC\u2085\u2080 = 280 nM)<\/p>\n<\/li>\n

      • \n

        Dopaminerge modulatieonderzoek<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Neurofysiologisch onderzoek<\/strong>:<\/p>\n

          \n
        • \n

          EEG-patroonanalyse bij proefdieren<\/p>\n<\/li>\n

        • \n

          Vergelijkende studies met klassieke psychedelica<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Metabolische pathway-analyse<\/strong>:<\/p>\n

            \n
          • \n

            O-demethyleringskinetiek<\/p>\n<\/li>\n

          • \n

            CYP2D6 interactieprofiel<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2697\ufe0f Experimentele Protocollen<\/strong><\/h4>\n

            Standaard onderzoekscondities:<\/em><\/p>\n

            \n\n\n\n\n\n\n
            Model<\/th>\nConcentratie<\/th>\nBlootstellingstijd<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10-100 \u03bcM<\/td>\n15-60 minuten<\/td>\n<\/tr>\n
            In vivo<\/td>\n1-5 mg\/kg<\/td>\nAcuut\/chronisch<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Opmerking: Toon niet-lineaire farmacokinetiek boven 8 mg\/kg*<\/p>\n

            \u26a0\ufe0f Veiligheidsprofiel<\/strong><\/h4>\n
              \n
            1. \n

              Toxicologische data<\/strong>:<\/p>\n

                \n
              • \n

                LD\u2085\u2080 (rat, oraal): 320 mg\/kg<\/p>\n<\/li>\n

              • \n

                NOAEL: 0,75 mg\/kg\/dag (28-daagse studie)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Bijwerkingenspectrum<\/strong>:<\/p>\n

                  \n
                • \n

                  Dosisafhankelijke effecten:<\/p>\n

                    \n
                  • \n

                    <3 mg\/kg: Subtiele sensorische veranderingen<\/p>\n<\/li>\n

                  • \n

                    3-6 mg\/kg: Vegetatieve symptomen<\/p>\n<\/li>\n

                  • \n
                    \n

                    6 mg\/kg: Potenti\u00eble hemodynamische instabiliteit<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n

                  • \n

                    Kritische interacties<\/strong>:<\/p>\n

                      \n
                    • \n

                      Gevaarlijk<\/strong>: MAO-remmers, sympathicomimetica<\/p>\n<\/li>\n

                    • \n

                      Risicovol<\/strong>: Serotonergische middelen, vasopressoren<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                      \ud83d\udcc9 Stabiliteitsgegevens<\/strong><\/h4>\n
                        \n
                      • \n

                        Houdbaarheid<\/strong>: 24 maanden bij -20\u00b0C (onder argon)<\/p>\n<\/li>\n

                      • \n

                        Degradatieproducten<\/strong>: <2% na 12 maanden RT<\/p>\n<\/li>\n

                      • \n

                        Compatibele buffers<\/strong>: PBS (pH 7,4), zoutzuur (0,1N)<\/p>\n<\/li>\n<\/ul>\n

                        \ud83d\udd0d Analytische Kenmerken<\/strong><\/h4>\n
                          \n
                        • \n

                          HPLC-retentietijd<\/strong>: 6,8 min (C18, 70:30 H\u2082O:MeCN)<\/p>\n<\/li>\n

                        • \n

                          Massaspectrum<\/strong>: [M+H]\u207a 240,2 m\/z<\/p>\n<\/li>\n

                        • \n

                          UV-absorptie<\/strong>: \u03bbmax 282 nm (\u03b5 = 4200)<\/p>\n<\/li>\n<\/ul>\n

                          \u2753 Onderzoeksgerichte FAQ<\/strong><\/h4>\n

                          Q1: Wat is het werkingsmechanisme?<\/strong>
                          \nA: Primaair 5-HT\u2082A receptorparti\u00eble agonist met secundaire DAT interactie.<\/p>\n

                          Q2: Hoe verhoudt de potentie zich tot mescaline?<\/strong>
                          \nA: ~3x hogere 5-HT\u2082A affiniteit maar lagere bloed-hersenbarri\u00e8repenetratie.<\/p>\n

                          Q3: Zijn er genotoxische risico’s?<\/strong>
                          \nA: Ames-test negatief tot 1 mM, maar beperkte chromosoomtestdata.<\/p>\n

                          Q4: Wat is het optimale formulering?<\/strong>
                          \nA: Steriele zoutoplossing (0,9% NaCl) voor in vivo studies.<\/p>\n

                          \ud83d\udccc Onderzoeksbeperkingen<\/strong><\/h4>\n
                            \n
                          • \n

                            Beperkte data over chronische blootstelling<\/p>\n<\/li>\n

                          • \n

                            Onbekende neuroplastische effecten<\/p>\n<\/li>\n

                          • \n

                            Variabele interspecies metabolisme<\/p>\n<\/li>\n<\/ul>\n

                            Wetenschappelijke disclaimer: Dit product is uitsluitend bestemd voor onderzoeksdoeleinden in geaccrediteerde laboratoria. Niet voor humaan of diergeneeskundig gebruik. Alle experimenten moeten voldoen aan relevante veiligheids- en ethische richtlijnen. Houd rekening met lokale regelgeving betreffende psychoactieve onderzoeksstoffen.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

                            Proscaline fumarate<\/span><\/span><\/h3>\n

                            Synonym:<\/span><\/span><\/strong> 3,5-dimethoxy-4-propoxyphenethylamine fumarate <\/span><\/span>
                            \nCAS Number:<\/span><\/span><\/strong> 39201-78-0 <\/span><\/span>
                            \nFormula:<\/span><\/span><\/strong> 2-{3,5-dimethoxy-4-propyloxyphenyl}ethan-1-amine fumarate <\/span><\/span>
                            \nMolar Mass:<\/span><\/span><\/strong> 355.4 g\/mol <\/span><\/span>
                            \nPurity:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":356,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[17,18,193],"product_tag":[22,194],"class_list":{"0":"post-340","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-fenethylamine","8":"product_cat-proscaline","9":"product_tag-nl","10":"product_tag-proscaline-fumarate","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/chemicalshoppers.com\/es\/wp-json\/wp\/v2\/product\/340","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chemicalshoppers.com\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/chemicalshoppers.com\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/chemicalshoppers.com\/es\/wp-json\/wp\/v2\/comments?post=340"}],"version-history":[{"count":1,"href":"https:\/\/chemicalshoppers.com\/es\/wp-json\/wp\/v2\/product\/340\/revisions"}],"predecessor-version":[{"id":16728,"href":"https:\/\/chemicalshoppers.com\/es\/wp-json\/wp\/v2\/product\/340\/revisions\/16728"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chemicalshoppers.com\/es\/wp-json\/wp\/v2\/media\/356"}],"wp:attachment":[{"href":"https:\/\/chemicalshoppers.com\/es\/wp-json\/wp\/v2\/media?parent=340"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/chemicalshoppers.com\/es\/wp-json\/wp\/v2\/product_brand?post=340"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/chemicalshoppers.com\/es\/wp-json\/wp\/v2\/product_cat?post=340"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/chemicalshoppers.com\/es\/wp-json\/wp\/v2\/product_tag?post=340"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}